#868: Tim’s Founder Kitchen — From Brainstorm to The President’s Office in Two Months (Featuring Jake Becraft, Strand Therapeutics)

エピソード概要

Jake Becraft is the CEO and co-founder of Strand Therapeutics, a company building one of the most advanced programmable genetic medicine platforms in biotechnology. Under his leadership, Strand is redefining what RNA medicines can do by enabling cell-selective targeting and therapeutic payload delivery inside the body, unlocking a new class of precision genetic therapies. This episode is brought to you by: Helix Sleep premium mattresses: HelixSleep.com/Tim (20% off any purchase) Incogni, which automatically removes your personal data from the web, helping shield you from fraud, scams, and identity theft: Incogni.com/Tim (use code TIM at checkout and get 60% off an annual plan) Timestamps: [00:00:00] Start. [00:06:07] What Strand does. [00:08:19] The Boston dinner. [00:11:05] The image of a body riddled with cancer. [00:15:05] What stuck for the muggles in the pitch deck. [00:17:14] A good drug vs. a good product. [00:19:40] Tricking cancer into snitching on itself. [00:27:38] The abscopal effect. [00:34:04] Potency, specificity, and delivery. [00:35:46] First principles thinking. [00:36:38] The precipice of a revolution. [00:41:14] The thousand people in the room. [00:48:38] Psychedelic medicine as a cautionary tale. [00:51:17] What actually catches a policymaker’s attention. [00:53:42] Breakthrough vs. incremental. [00:54:55] What’s in it for the policymakers? [00:58:08] The 80/20 wish list. [01:01:31] Australia’s CTN system. [01:03:51] Sheep, psychedelics, and red-tape arbitrage. [01:05:22] China’s clinical-trial flywheel vs. slow-motion American loss. [01:06:53] The bicoastal biotech ethos. [01:08:10] Can the FDA actually pull this off? [01:12:12] The Sophie’s Choice of pharma development. [01:14:16] Lost arts of founder mode. [01:15:23] Rockets for tumors, T-cells, and beyond. [01:19:16] Viral in policy circles. [01:23:09] The Washington Post headline and the PickFu split test. [01:27:56] Solution-first storytelling. [01:33:54] RNA medicine and platform ther